杨斌

职称：教授

性别：男

籍贯：湖南永州

出生年月：1987.11

移动电话：

家庭电话：

家庭住址：

电子邮箱：binyang@xtu.edu.cn

工作学习经历

主讲课程

《分析化学》、《分析化学实验》、《仪器分析实验》、《综合化学实验》等

研究方向 

DNA荧光传感方法及其分析检测应用 

主要学术成果和成绩 

[1] Zihua Guo, Yinping Deng, Bin Yang*, Weiyi Lu, Zhen Tian. Learning From Classic: DNA-based Conditional Equilibrium Constant to Regulate Affinity “On-the-fly” for Bioassays, Analytical Chemistry, 2024, 96, 15457−15465. 

[2] Zihua Guo, Bin Yang*, Weiyi Lu, Zhen Tian, Huimin Hao. Photocatalytic Aptamer Chemiluminescent System for Homogeneous, Reliable, Label-Free, Generic Assay of Small Molecules, Analytical Chemistry, 2024, 96, 3655-3661.

[3] Huimin Hao, Hanfen Cai, Bin Yang*, Shuyan Lou, Zihua Guo, Weiyi Lu, Zhen Tian, Versatile DNA Balances via Adjacent Base Stacking for Homogeneous Assay of Energy Parameters, Small Molecules, And Ribonuclease, Analytical Chemistry, 2023, 95, 14643-14650. 

[4] Huimin Hao, Ye Li, Bin Yang*, Shuyan Lou, Zihua Guo, Weiyi Lu, Simulation-Guided Rational Design of DNA Probe for Accurate Discrimination of Single-Nucleotide Variants Based on “Hill-Type”Cooperativity, Analytical Chemistry, 2023, 95, 2893-2900. 

[5] Pan Hu, Mengmeng Li, Xijiao Wei, Bin Yang*, Ye Li, Chun-Yan Li, Jun Du, Cooperative Toehold: A Mechanism To Activate DNA Strand Displacement and Construct Biosensors, Analytical Chemistry, 2018, 90, 9751-9760. 

[6] Weiyi Lu, Bin Yang*, Zihua Guo, Zhen Tian, et al. Machine learning-based fluorescence sensor array: Accurate discrimination, quantitative assay of phenothiazine drugs via versatile DNA probes, Sensors and Actuators B: Chemical, 2024, 405, 135330.

[7] Zihua Guo, Bin Yang*, Jian Zhu , Shuyan Lou , Huimin Hao , Weiyi Lu, Light-activated, dual-mode fluorescence and colorimetric detection of estradiol with high fidelity based on aptamer’s special recognition, Food Chemistry, 2024, 436, 137702.

[8] Huimin Hao , Jian Zhu , Bin Yang *, Li Peng, Shuyan Lou, Ovalbumin-coated gold nanoparticles with interesting colloidal stability for colorimetric detection of carbaryl in complex media, Food Chemistry, 2023, 403, 134485.

[9] Jian Zhu, Bin Yang*, Li Peng, Jinwei Wu, Huimin Hao, Shuyan Lou, Target-triggered double fluorescent biosensors for rapid and sensitive detection of long-chain perfluorinated compounds using DNA probe and lysozyme fiber, Science of The Total Environment, 2023, 860, 160496.

[10] Weiyi Lu, Shuyan Lou, Bin Yang*, Meixuan Wu , Huimin Hao , Zihua Guo, Light-activated nanozymes (adenosine monophosphate-Ce³⁺-fluorescein) for colorimetric detection of carbaryl by breaking a pH limitation, Sensors and Actuators B: Chemical, 2023, 396, 134548.

[11] Huimin Hao, Li Peng, Bin Yang*, Guo-Jiang Mao, Jian Zhu, Shuyan Lou, Macromolecules-triggered, light-activated oxidase mimic for versatile colorimetric biosensors with signal-switching functionality, Sensors and Actuators B: Chemical, 2023, 381, 134090.

[12] Jian Zhu, Bin Yang*, Huimin Hao Li Peng, Shuyan Lou, Gold nanoparticles-based colorimetric assay of pesticides: A critical study on aptamer’s role and another alternative sensor array strategy, Sensors and Actuators B: Chemical, 2023, 381, 133439.

[13] Jian Zhu, Zhu Su, Bin Yang*, Li Peng, Huimin Hao, Shuyan Lou, Transient toehold: An interesting transient molecular event for controlled DNA displacement reactions and assay of progesterone with aptamer probe, Sensors and Actuators B: Chemical, 2022, 367, 132077.

[14] Yinping Deng, Jun Du, Donghua Chen, Guo-Jiang Mao, Bin Yang*, Yin Zhang, Zhu Su, Hanfen Cai, Junction toehold: A novel approach for flexible DNA strand displacement and bioassay, Sensors and Actuators B: Chemical, 2021, 347, 130645. 

[15] Jun Du, Ye Li, Bin Yang*, Yin Zhang, Zhu Su. Allosteric DNA molecular beacons: Using a novel mechanism to develop universal biosensor arrays to fully discriminate DNA/RNA analogues. Sensors and Actuators B: Chemical, 2020, 311, 127908. 

[16] Mengmeng Li, Jun Du, Ye Li, Xijiao Wei, Bin Yang*, Yin Zhang, Zhu Su. Abundant cross reactivity in DNA circuits: An efficient and universal strategy to develop sensor arrays. Sensors and Actuators B: Chemical, 2019, 301, 127066. 

[17] Xijiao Wei, Mengmeng Li, Pan Hu, Bin Yang*, Programmable binary chimera aptamer probes for intelligent fluorescence imaging of cell membrane receptors, Sensors and Actuators B: Chemical, 2017, 241, 422-429. 

[18] Weiyi Lu, Shuyan Lou, Bin Yang*, Zihua Guo, Zhen Tian, Light-activated oxidative capacity of isoquinoline alkaloids for universal, homogeneous, reliable, colorimetric assays with DNA aptamers, Talanta, 2024, 279, 126667.

[19] Li Peng, Jian Zhu, Bin Yang*, Huimin Hao, Shuyan Lou, A green photocatalytic-biosensor for colorimetric detection of pesticide (carbaryl) based on inhibition of acetylcholinesterase, Talanta, 2022, 246, 123525.

[20] Pan Hu, Bin Yang*, Cleavable DNA-protein hybrid molecular beacon: A novel efficient signal translator for sensitive fluorescence anisotropy bioassay, Talanta, 2016, 147, 276-281. 

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个人简介 

教授，理学博士，硕士生导师；1987年生，汉族，中共党员。2009-2014年在湖南大学分析化学专业硕博连读，师从谭蔚泓院士和张晓兵教授。目前在3044am永利集团-分析化学教研室，主要从事分析化学的教学、DNA荧光传感方法的科研工作。

主持了国家自然科学基金青年项目、横向项目、省教改重点项目等课题，以唯一通讯作者在Analytical Chemistry、Sensors and Actuators B: Chemical等期刊上发表一区SCI论文20余篇，并获得了2021年湖南省自然科学三等奖(排名第1)。担任了2016级应用化学2班班主任，共指导了20余名研究生(含毕业)，且指导的研究生多次获得国家奖学金、董事长奖学金、优秀毕业生等荣誉。