欧阳娟

职称：副教授

性别：女

职务：

办公电话：

移动电话：

家庭电话：

家庭住址：

电子邮箱：oyj2023@xtu.edu.cn

工作学习经历

主讲课程

《分析化学》、《分析化学实验》

研究方向

功能光学材料（包括荧光、光声和化学发光探针，以及智能纳米材料）的设计、合成及应用

主要学术成果

承担项目（主持）：

[1] 国家自然科学基金-青年基金项目，代谢酶激活型靶向近红外化学发光探针的构建及在细菌感染疾病成像中的应用，2025-2027年；

[2] 中国博士后科学基金第76批面上资助，细菌靶向性双锁串联荧光探针的构建及其在尿路感染中的成像研究，2024-2026年；

[3] 湖南省自然科学基金-青年基金项目，基于主客体策略的纳米体系的构建及在细菌生物被膜感染疾病诊断和治疗中的应用，2024-2026年；

[4] 广东省自然科学基金面上项目，多功能超分子纳米体系的构建及在牙周病诊断和治疗中的应用，2024-2026年；

[5] 3044am永利集团人才引进科研启动项目，靶向性多功能光学探针的构建及在自身免疫性疾病中的应用，2023-2029年；

[6] 中国博士后科学基金第72批面上资助，抗菌-抗炎症纳米诊疗体系的构建及其在牙周病中的应用，2023年；

[7] 湖南省研究生科研创新项目，靶向线粒体的三磷酸腺苷比率荧光探针的构建及细胞成像研究，2017-2019年。

发表学术论文：

2024年

[1] Zhi-Chao Yang, Zhi-Hao Yang, Zhi-Qing Wang, Yao Li, Guo-Jiang Mao, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, Zero-crosstalk tumor-targeting ratiometric near-infrared γ-glutamyltranspeptidase probe for fluorescent-guided surgical resection of orthotopic hepatic tumor. Analytical Chemistry, 2024. (通讯作者，IF = 6.7)；

[2] Wei-Qun Deng, Jun-Tao Chen, Si-Si Chen, Zhi-Qing Wang, Guo-Jiang Mao, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, ATP-responsive copper(II)-doped ZIF-nanoparticles for synergistic cancer therapy: combining cuproptosis and chemo/chemodynamic therapy. Journal of Materials Chemistry B, 2024, 12, 11414. (通讯作者，IF = 6.1)

[3] Si-Si Chen, Xiao-Fan Xu, Wei-Qun Deng, Guo-Jiang Mao, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, An ATP-responsive ZIF-based NIR fluorescence nanosystem for enhanced chemo-photodynamic therapy of tumors. Nanoscale, 2024, 16, 20617. (通讯作者，IF = 5.8)

[4] Zhi-Chao Yang, Qing-Song Gu, Jing-Jing Chao, Fang-Yuan Tan, Guo-Jiang Mao, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, Glutathione-activated biotin-targeted dual-modal imaging probe with improved PDT/PTT synergistic therapy. Analytica Chimica Acta, 2024, 1316, 342860. (通讯作者，IF = 5.7)

[5] Juan Ouyang, Lihe Sun, Zunpan She, Rong Li, Fang Zeng, Zhicheng Yao, Shuizhu Wu, Microneedle system with biomarker-activatable chromophore as both optical imaging probe and anti-bacterial agent for combination therapy of bacterial-infected wounds and outcome monitoring. ACS Applied Materials & Interfaces, 2024, 16, 20315-20328. (IF = 8.3)

[6] Lihe Sun, Juan Ouyang, Zunpan She, Rong Li, Fang Zeng, Zhicheng Yao, Shuizhu Wu, Injectable-hydrogel-based tissue sealant for hemostasis, bacteria inhibition, and pro-angiogenesis in organ bleeding wounds and therapeutic outcome monitoring via NIR-II optical imaging. Advanced Healthcare Materials, 2024, 13, 2303997. (共同一作，IF = 10.0)

2024年以前

[1] Juan Ouyang, Lihe Sun, Zhou Zeng, Cheng Zeng, Fang Zeng, Shuizhu Wu, Nanoaggregate probe for breast cancer metastasis through multispectral optoacoustic tomography and aggregation-induced NIR-I/II fluorescence imaging. Angewandte Chemie International Edition, 2020, 59, 10111-10121. (IF = 16.1)；

[2] Juan Ouyang, Lihe Sun, Fang Zeng, Shuizhu Wu, Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging. Coordination Chemistry Reviews, 2022, 456, 214438. (IF = 20.3)

[3] Juan Ouyang, Lihe Sun, Jiayue Pan, Zhuo Zeng, Cheng Zeng, Fang Zeng, Mei Tian, Shuizhu Wu, A targeted nanosystem for detection of inflammatory diseases via fluorescent/optoacoustic imaging and therapy via modulating Nrf2/NF-κB pathways. Small, 2021, 17, 2102598. (IF = 13.0)

[4] Lihe Sun^#, Juan Ouyang^#, Fang Zeng, Shuizhu Wu, An AIEgen-based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT/NIR-II fluorescent imaging and inhibiting NLRP3 inflammasome. Biomaterials, 2022, 283, 121468. (共同一作，IF = 12.8)

[5] Lihe Sun^#, Juan Ouyang^#, Zhuo Zeng, Cheng Zeng, Yunqing Ma, Fang Zeng, Shuizhu Wu, Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-κB/NLRP3 pathways. Bioactive Materials, 2022, 10, 79-92. (共同一作，IF = 18.0)

[6] Juan Ouyang, Lihe Sun, Fang Zeng, Shuizhu Wu, Rational design of stable heptamethine cyanines and development of a biomarker-activatable probe for detecting acute lung/kidney injuries via NIR-II fluorescence imaging. Analyst, 2022, 147, 410-416. (IF = 3.6)

[7] Lihe Sun^#, Juan Ouyang^#, Yunqing Ma, Zhuo Zeng, Cheng Zeng, Fang Zeng, Shuizhu Wu, An activatable probe with aggregation-induced emission for detecting and imaging herbal medicine induced liver injury with optoacoustic imaging and NIR-II fluorescence imaging. Advanced Healthcare Materials, 2021, 10, 2100867. (共同一作，IF = 10.0)

[8] Zhou Zeng^#, Juan Ouyang^#, Lihe Sun, Cheng Zeng, Fang Zeng, Shuizhu Wu, Activatable nanocomposite probe for preoperative location and intraoperative navigation for orthotopic hepatic tumor resection via MSOT and aggregation-induced near-IR-I/II fluorescence imaging. Analytical Chemistry, 2020, 92, 9257-9664. (共同一作，IF = 6.7)

[9] Juan Ou-Yang, Yongfei Li, Wen-Li Jiang, Shuang-Yan He, Hong-Wen Liu, Chun-Yan Li, Fluorescence-guided cancer diagnosis and surgery by a zero cross-talk ratiometric near-infrared γ‑glutamyltranspeptidase fluorescent probe. Analytical Chemistry, 2019, 91, 1056-1063. (IF = 6.7)

[10] Juan Ou-Yang, Yongfei Li, Ping Wu, Wen-Li Jiang, Hong-Wen Liu, Chun-Yan Li, Detecting and imaging of γ‑glutamytranspeptidase activity in serum, live cells, and pathological tissues with a high signal-stability probe by releasing a precipitating fluorochrome. ACS Sensors, 2018, 3, 1354-1361. (IF = 8.2)

[11] Juan Ou-Yang, Wen-Li Jiang, Kai-Yue Tan, Hong-Wen Liu, Song-Jiao Li, Juan Liu, Yongfei Li, Chun-Yan Li, Two-photon fluorescence probe for precisely detecting endogenous H₂S in lysosome by employing a dual lock system. Sensors and Actuators B: Chemical, 2018, 260, 264-273. (IF = 8.0)

[12] Juan Ou-Yang, Chun-Yan Li, Yongfei Li, Bin Yang, Song-Jiao Li, An infinite coordination polymer nanoparticles-based near-infrared fluorescent probe with high photostability for endogenous alkaline phosphatase in vivo. Sensors and Actuators B: Chemical, 2018, 255, 3355-3363. (IF = 8.0)

[13] Juan Ou-Yang, Chun-Yan Li, Yongfei Li, Junjie Fei, Fen Xu, Song-Jiao Li, Shi-Xin Nie, A rhodamine-based fluorescent probe with high water solubility and its application in the detection of glutathione with unique specificity. Sensors and Actuators B: Chemical, 2017, 240, 1165-1173. (IF = 8.0)

[14] Zhi Li^#, Juan Ou-Yang^#, Ya-Jun Fu, Chun-Yan Li, Yongfei Li, Song-Jiao Li, A borondipyrrolemethene-based turn-on fluorescent probe for silver ion with high sensitivity and selectivity and its application in water samples and living cells. Tetrahedron Letters, 2017, 58, 3536-3540. (共同一作，IF = 1.5)

授权专利：

[1] 基于罗丹明的GSH水溶性荧光探针的制备方法和应用，专利号ZL201610821181.3；

个人简介

欧阳娟，女，湖南株洲人，中共党员。2015年本科毕业于3044am永利集团化工学院；2018年硕士毕业于3044am永利集团，师从李春艳教授；2021年博士毕业于华南理工大学材料科学与工程学院，师从吴水珠教授；随后留校继续博士后研究，合作导师为曾钫教授和吴水珠教授。2023年11月加入3044am永利集团李春艳教授团队，硕士研究生导师，主要从事分子光学探针设计合成、多功能纳米诊疗体系的构建及其传感/检测/成像、诊断与治疗等方面的应用研究。相关成果在Coordination Chemistry Reviews, Angewandte Chemie International Edition, Small, Biomaterials, Bioactive Materials, Analytical Chemistry等国际著名期刊上发表论文35篇（其中一作含共同一作论文16篇，通讯作者文章4篇），国家授权发明专利1项，先后主持国家自然科学基金-青年基金项目、中国博士后科学基金面上资助项目、湖南省自然科学基金-青年基金项目、广东省自然科学基金-面上项目、湖南省研究生科研创新项目和3044am永利集团人才引进科研启动项目等科研项目7项，并参与国家自然科学基金-面上项目数项。曾获得“湖南省优秀硕士学位论文”、“博士研究生国家奖学金”、“华南理工大学董事长奖学金”、“湘潭市自然科学优秀学术论文一等奖”、“3044am永利集团特等董事长奖学金”和“硕士研究生国家奖学金”等荣誉。

学术主页：https://www.researchgate.net/profile/Juan-Ouyang-4/publications

欢迎大家踊跃报考课题组研究生，一起探索功能光学材料的奥秘！

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